Best Ergonomic Mice 2025: Say Goodbye to Wrist Pain and Hello to All-Day Comfort

If you're spending hours clicking and scrolling every day, your wrist is probably crying out for help. That traditional flat mouse? It's forcing your hand into an unnatural position that can lead to carpal tunnel syndrome, repetitive strain injury, and general discomfort that makes every workday a pain—literally.

The good news? Ergonomic mice have come a long way, and 2025's models are game-changers. We're talking about designs that cradle your hand in natural positions, reduce muscle strain, and let you work all day without that nagging ache. Whether you're a developer crushing code, a designer perfecting pixels, or just someone who's tired of wrist pain, there's an ergonomic mouse that'll transform your computing experience.

We've tested dozens of ergonomic mice to find the ones that truly deliver on comfort, precision, and performance. Here are the absolute best.

Logitech MX Vertical – The Premium Vertical Powerhouse

Price: $99.99

What we like: This is the ergonomic mouse that converted us to vertical believers. The 57-degree vertical angle keeps your hand in a natural handshake position, dramatically reducing forearm strain. The precision is phenomenal—a 4,000 DPI sensor that you can adjust on the fly. Battery life? A whopping four months on a single charge, and a quick one-minute charge gives you three hours of use. The textured rubber grip feels premium, and it works seamlessly across multiple devices with Logitech's Flow technology.

Other things to know: Takes about a week to fully adjust to the vertical orientation, but once you do, there's no going back. Works with both USB-C charging and Bluetooth. Available for both right-handed users (the standard model) and left-handed users need to look elsewhere. Slightly heavier than traditional mice at 4.76 oz, but the weight feels balanced and premium.

Logitech ERGO M575 Trackball – The Stationary Comfort King

Price: $49.99

What we like: Your wrist literally doesn't move with this trackball design—your thumb does all the work. Perfect if you have limited desk space or existing wrist issues. The precision mode button lets you switch between speed and accuracy instantly. Battery lasts an incredible 24 months on a single AA battery. The contoured shape fits your palm perfectly, and the 33-degree angle provides natural comfort without the dramatic adjustment period of vertical mice.

Other things to know: The trackball requires a different muscle memory—your thumb controls cursor movement instead of your whole arm. Most users adapt within 2-3 days. The trackball itself is removable for cleaning (and it will need cleaning every few months). Connects via Bluetooth or the included USB receiver. Available in both graphite and off-white to match your setup.

Anker Wireless Vertical Mouse – The Budget-Friendly Winner

Price: $25.99

What we like: Proof that ergonomic doesn't have to mean expensive. This vertical mouse delivers the same hand-in-handshake-position comfort as mice triple its price. Five adjustable DPI levels (800/1200/1600/2000/2400) let you find your perfect sensitivity. The textured side grips prevent slipping, and the battery life is solid at 3-4 months of regular use. Connects instantly via the included 2.4GHz USB receiver with no lag.

Other things to know: Not as refined as premium options—the clicks are slightly louder and the scroll wheel has a bit more resistance. No Bluetooth option, only the USB receiver. The build feels plastic-y compared to premium mice, but it's sturdy enough for daily use. Only comes in black. No left-handed version available. For the price, it's an absolute steal for anyone wanting to try ergonomic mice without breaking the bank.

Microsoft Sculpt Ergonomic Mouse – The Thumb-Rest Champion

Price: $54.99

What we like: That oversized thumb rest is a revelation—it supports your thumb in a relaxed position that eliminates tension through your entire hand. The dome shape fits naturally under your palm, and the Windows button gives you instant access to the Start menu (works on Mac too, just without that specific function). The angle is gentle enough that there's almost no adjustment period. Includes a separate magnetic detachable number pad that's perfect for data entry.

Other things to know: Requires two AAA batteries (included) that last about 6-8 months. The USB receiver is tiny and tucks away nicely. The mouse is larger than standard mice, so it works best for medium to large hands—small-handed users might find it unwieldy. The scroll wheel is satisfyingly clicky. Only available in matte black. No rechargeable option.

Kensington Pro Fit Ergo Vertical Mouse – The Adjustable Angle Expert

Price: $69.99

What we like: The standout feature here is the adjustable angle—you can set it at 60 degrees for maximum ergonomic benefit or dial it back to 50 degrees if you want something less dramatic. The soft-touch coating feels great during long sessions, and the precision 2400 DPI optical sensor tracks perfectly on almost any surface. Six programmable buttons let you customize your workflow. Available in both wireless and wired versions.

Other things to know: The adjustment mechanism is solid but not something you'll change daily—pick your angle and stick with it. Wireless version uses a USB receiver (no Bluetooth). Battery life is about 18 months with two AAA batteries. The size is substantial—best for medium to large hands. Kensington's TrackballWorks software lets you customize buttons, but it's optional. Available in black or white.

Logitech Lift Vertical Ergonomic Mouse – The Compact Comfort Choice

Price: $69.99

What we like: Specifically designed for smaller hands, the Lift is a godsend for anyone who finds most ergonomic mice too bulky. The 57-degree angle delivers full ergonomic benefits in a more compact package. Whisper-quiet clicks are perfect for shared workspaces or late-night sessions. The soft textured grip feels premium, and the battery lasts up to two years on a single AA battery. Connects via Bluetooth or the included Logi Bolt USB receiver.

Other things to know: Available in three gorgeous colors: graphite, rose, and off-white. The size is genuinely smaller—if you have large hands, go with the MX Vertical instead. Four buttons total (left, right, middle, back). The scroll wheel is smooth and precise. Works with Logitech Options+ software for customization. Comes in both left-handed and right-handed versions, which is rare for ergonomic mice.

J-Tech Digital V628 Vertical Mouse – The Wired Performance Beast

Price: $39.99

What we like: For those who prefer the zero-latency reliability of a wired connection, this is your mouse. Six adjustable DPI levels from 1000 to 2400 let you dial in perfect precision. The vertical design reduces forearm twisting by 25% compared to traditional mice (yes, they actually measured it). Removable palm rest lets you customize the fit. The braided cable is 6 feet long and tangle-resistant.

Other things to know: The wired connection means one less device to charge, but also means dealing with a cable. The removable palm rest is a nice touch, but most users prefer keeping it attached. Five programmable buttons can be customized via downloadable software. The LED indicator shows your current DPI setting. Only available in black. Best for medium to large hands. No Mac-specific software, but basic functions work perfectly on Mac.

What to Look for in an Ergonomic Mouse

Hand Size Matters: Most ergonomic mice are designed for medium to large hands. If you have smaller hands, look for models specifically labeled as compact or small-hand-friendly (like the Logitech Lift).

Vertical vs. Trackball vs. Contoured: Vertical mice keep your hand in a handshake position. Trackballs keep your wrist stationary while your thumb or fingers move the cursor. Contoured mice have gentler angles and thumb rests. Try to identify which type of strain you're experiencing to choose the right solution.

Adjustment Period: Expect 3-7 days to fully adapt to a new ergonomic mouse, especially vertical or trackball designs. Your accuracy will temporarily decrease, but stick with it—the long-term comfort benefits are worth it.

Wireless vs. Wired: Wireless offers freedom and cleaner desks but requires charging or battery changes. Wired offers zero latency and no charging hassles. For gaming or precision work, wired might be preferable. For general use, wireless is more convenient.

DPI and Precision: Higher DPI means less hand movement for cursor travel. If you have wrist pain, higher DPI settings can reduce the range of motion required. Look for mice with adjustable DPI so you can find your sweet spot.

The Bottom Line

If you're dealing with wrist pain, don't wait for it to get worse. An ergonomic mouse is one of the most impactful upgrades you can make to your workspace, and with options starting at just $26, there's no reason to keep suffering through your workday.

Our top pick for most people is the Logitech MX Vertical—it's the perfect balance of comfort, precision, and features. If you're on a budget, the Anker Wireless Vertical Mouse delivers shocking value. And if you have smaller hands or work in quiet environments, the Logitech Lift is absolutely perfect.

Your wrist will thank you. Trust us on this one.